Knee osteoarthritis is a common complaint. Generally, it’s managed conservatively with exercise, until a person requires an partial or full knee replacement. Prolotherapy offers an effective solution for joints that are excessively lax, causing proliferation of ligament tissue, and ‘strengthening’ of the joint, stopping further cartilage and bone wear and tear. Patients with knee OA were x-rayed before and after Prolotherapy. The changes seen in the knee joint are reflective of the regenerative power of Prolotherapy.